What is Rapamycin ?
Rapamycin (Sirolimus)is an mTOR inhibitor traditionally used as an immunosuppressant in transplant medicine. In recent years, it has gained growing interest in the field of longevity and anti-aging medicine due to its ability to modulate cellular aging, inflammation, and metabolic health. When dosed intermittently and at low levels, Rapamycin may help extend lifespan, delay age-related disease onset, and support health span without the immune suppression associated with high-dose use.
Benefits:
- May extend lifespan and delay age-related disease
- Supports cellular autophagy and DNA repair
- Reduces chronic inflammation (“inflammaging”)
- Improves metabolic health and insulin sensitivity
- Works synergistically with fasting, exercise, and AMPK activators (e.g., Metformin)
How does it work ?
Rapamycin works by selectively inhibiting the mammalian target of rapamycin complex 1 (mTORC1), a key regulator of aging and growth:
- mTORC1 Inhibition
• mTORC1 controls cell growth, proliferation, and protein synthesis. Rapamycin slows this pathway, promoting cellular repair, autophagy, and metabolic efficiency—hallmarks of anti-aging.
Intermittent, Low-Dose Strategy
• When used once or twice weekly at low doses, it avoids immunosuppression while preserving its anti-aging and regenerative benefits.
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- Week 2–4:Subtle improvement in recovery, inflammation, skin tone
- Week 6–12:Better metabolic flexibility, energy, and clarity
- 6–12 months:Long-term benefits on insulin sensitivity, lipid markers, and cellular health
- Optimal when combined withMetformin, exercise, time-restricted eating, NAD+ support
- Missed dose? Take on your next scheduled day—do not double dose
Common (Usually mild at low/intermittent doses):
- Mouth ulcers or canker sores
- Gastrointestinal discomfort
- Headache or fatigue
- Mild immunosuppression (dose-dependent)
Less Common / Monitor If Present:
- Elevated triglycerides or cholesterol
- Impaired wound healing
- Increased risk of infection at high doses
- Menstrual irregularities
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