What is LDN ?
Low Dose Naltrexone (LDN) is a compounded, low-dose formulation of the opioid receptor antagonist naltrexone. At lower dosages, it works differently than standard naltrexone—modulating the immune system and reducing chronic inflammation. It is used off-label for a range of conditions including autoimmune diseases, chronic pain, fibromyalgia and mood disorders. At low doses, LDN temporarily blocks opioid receptors, which causes the body to upregulate endorphin production—creating lasting anti-inflammatory and immune-calming effects.
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Low Dose Naltrexone functions through transient opioid receptor blockade, which stimulates the body’s natural healing response
Common (initial/transient):
- Vivid dreams or sleep disturbances (typically improve in 7–10 days)
- Mild headache or nausea
- Temporary increase in autoimmune symptoms (rare, resolves)
Less Common:
- Anxiety or mood changes
- Restlessness at night
- Hypothyroid symptoms if thyroid dose isn’t adjusted (in Hashimoto’s)
Note: LDN should not be taken with opioid pain medications. It may block their effect.
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